Accession Number:

AD1046254

Title:

Prophylactic Administration of CN-105 Confers Neuroprotection Against Acute Brain Injury

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

Duke University Durham United States

Personal Author(s):

• Laskowitz, Daniel

Report Date:

2017-10-01

Pagination or Media Count:

44.0

Abstract:

We have previously established that the pentapeptide CN-105 Ac-VSRRR-COOH improves functional and outcome and reduces histological injury in a murine model of traumatic brain injury closed head injury caused by fluid percussion against the intact skull. The major goal of this project is to establish whether this neuroprotective pentapeptide would be effective in mitigating secondary neuronal injury and improving functional outcomes when administered prior to closed head injury, as this would be a potentially viable strategy to reduce morbidity of traumatic brain injury associated with combat. As described in the statement of work, during the initial year of this proposal, we have tested the efficacy of CN-105 when administered prophylactically in both a moderate single head injury, and paradigm of milder head injuries occurring on a weekly basis over 5 weeks. In addition, we performed the initial work comparing the bioavailability and pharmacokinetics between intravenous, intraperitoneal, intranasal, and oral modes of administration.

Descriptors:

• peptides
• brain injuries
• trauma
• NEUROPROTECTIVE DRUGS
• neurons
• morbidity
• pharmacokinetics
• inflammation
• histology

Subject Categories:

• Medicine and Medical Research
• Biochemistry
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE