Optimization of Delayed Tolerance Induction in Swine: A Clinically-Relevant Protocol for Immunosuppression-Free Vascularized Composite Allotransplantation
Technical Report,15 Sep 2016,14 Sep 2017
Massachusetts General Hospital Boston United States
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This research project addresses the FY15 RTR Focus Areas of Understanding mechanisms of immune rejection and Immunomodulation approaches and mechanisms e.g., tolerance induction, chimerism. Tolerance of kidney allografts has been achieved in nonhuman primates NHPs using a the delayed period protocol, i.e. combination of post transplant non-myeloablative conditioning and donor bone marrow transplantation four months later DBMT.
- Medicine and Medical Research
- Anatomy and Physiology