Accession Number:

AD1046206

Title:

Optimization of Delayed Tolerance Induction in Swine: A Clinically-Relevant Protocol for Immunosuppression-Free Vascularized Composite Allotransplantation

Descriptive Note:

Technical Report,15 Sep 2016,14 Sep 2017

Corporate Author:

Massachusetts General Hospital Boston United States

Personal Author(s):

• Cetrulo, Curtis L.

Report Date:

2017-10-01

Pagination or Media Count:

15.0

Abstract:

This research project addresses the FY15 RTR Focus Areas of Understanding mechanisms of immune rejection and Immunomodulation approaches and mechanisms e.g., tolerance induction, chimerism. Tolerance of kidney allografts has been achieved in nonhuman primates NHPs using a the delayed period protocol, i.e. combination of post transplant non-myeloablative conditioning and donor bone marrow transplantation four months later DBMT.

Descriptors:

• surgical transplantation
• grafts
• Immunomodulation
• immunosuppression
• bone marrow

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE