Improving Ischemia Reperfusion Injury in Vascularized Composite Tissue Allotransplantation Via Histone Deacetylase Modulation
[Technical Report, Annual Report]
Trustees of the University of Pennsylvania
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This work proposes to investigate the impact of histone deacetylase HDAC drug inhibition or deletion on the tolerance of limb warm and cold ischemia reperfusion injury IRI in scenarios relevant to limb transplantation using mouse models for experimentation. Limitations in tolerated ischemia times limits the scope of donors that can be considered for any particular vascularized composite allotransplant VCA recipient. Mitigating IRI therapeutically would have significant impact on the applicability of VCA to military personnel suffering catastrophic limb or tissue loss.
- Medicine and Medical Research