Prostate Specific Membrane Antigen (PSMA) Targeted Bio-orthogonal Therapy for Metastatic Prostate Cancer
Technical Report,15 Sep 2016,14 Sep 2017
John Hopkins University Baltimore United States
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During the first year of the project we have identified new monoclonal anti-PSMA antibodymAb, which demonstrated high affinity to the PSMA receptor and excellent targeting of PSMA expressing prostate cancer cells both in vitro and in vivo. We investigated details of them Ab and therapeutic complexes internalization in these cells and demonstrated rapid perinuclear localization of internalized agents. We have also synthesized and tested click reactive components for in vivo therapy. First in vivo data for anti-PSMA click-based pretargeting have been obtained with NIR in vivo optical imaging. In addition, all regulatory reviews of the proposed animal procedures have been successfully completed.
- Medicine and Medical Research