Early Detection of Clinically Significant Prostate Cancer Using Ultrasonic Acoustic Radiation Force Impulse (ARFI) Imaging
Technical Report,15 Sep 2016,14 Sep 2017
Duke University Durham United States
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Prostate cancer PCa is the second most common cancer in men in the United States, with over 220,000 cases newly diagnosed, and over 27,000 deaths annually 1. The current standard of care for prostate cancer diagnosis is to perform ultrasound guided biopsies is specific locations in the prostate, however, because prostate cancer does not have a unique appearance in ultrasound, these biopsies are not targeted to regions that look like cancer. As a result, these biopsy procedures can miss, leading to an incorrect diagnosis. Many men with prostate cancer have multiple separate biopsy procedures before finding it. Another problem is that cancer often occurs in multiple places in the prostate, and, the current biopsy approach does not necessarily find the most aggressive cancer in the prostate. We have preliminary data supporting the hypothesis that the 3D ARFI imaging biopsy targeting system we propose to develop will enable visualization of the most aggressive cancer in the prostate. Our system uses ultrasound to make pictures of how stiff tissues are and provides different information than normal ultrasound images. Therefore, the system will be low-cost, and can be easily incorporated into Urology clinics where biopsies are normally performed. If successful, our system will enable first time biopsy procedures to be targeted toward the most aggressive cancer in the prostate.
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