Curcumin Nanoparticle Therapy for Gulf War Illness
Technical Report,30 Sep 2016,29 Sep 2017
The Texas A and M University System College Station United States
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The major goal of this project is to examine the efficacy of oral administration of curcumin CUR encapsulated biodegradable polymer nanosystems nCUR for alleviating cognitive, memory and mood impairments in a rat model of gulf war illnessGWI. Specific Aim 1 studies involve quantification of the efficacy of oral administration of different doses of nCUR for improving neurogenesis and suppressing inflammation and oxidative stress in the hippocampus. Specific Aim 2 studies will examine whether an apt dose of nCUR treatment based on Specific Aim 1 studies is efficient for alleviating cognitive, memory and mood impairments in GWI-rats, when treatment is commenced at an extended time-point 8-months after exposure to GWIR chemicals and stress. During the past year, a set of experiments related to Specific Aim 1 studies was performed 1 Exposure of rats to GWI related chemicals and moderate stress.
- Medicine and Medical Research