Accession Number:

AD1045514

Title:

Curcumin Nanoparticle Therapy for Gulf War Illness

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

The Texas A and M University System College Station United States

Personal Author(s):

Report Date:

2017-10-01

Pagination or Media Count:

13.0

Abstract:

The major goal of this project is to examine the efficacy of oral administration of curcumin CUR encapsulated biodegradable polymer nanosystems nCUR for alleviating cognitive, memory and mood impairments in a rat model of gulf war illnessGWI. Specific Aim 1 studies involve quantification of the efficacy of oral administration of different doses of nCUR for improving neurogenesis and suppressing inflammation and oxidative stress in the hippocampus. Specific Aim 2 studies will examine whether an apt dose of nCUR treatment based on Specific Aim 1 studies is efficient for alleviating cognitive, memory and mood impairments in GWI-rats, when treatment is commenced at an extended time-point 8-months after exposure to GWIR chemicals and stress. During the past year, a set of experiments related to Specific Aim 1 studies was performed 1 Exposure of rats to GWI related chemicals and moderate stress.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE