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Pathomechanics of Post-Traumatic OA Development in the Military Following Articular Fracture

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Technical Report,30 Sep 2015,29 Sep 2016

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The Geneva Foundation Tacoma United States

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The objective of the proposed research is to develop new models for predicting the risk of post-traumatic osteoarthritis PTOA following intra-articular fracture IAF. Aim 1, pursued this year, involved evaluating pre- and post-treatment CT data from patients with combat-related IAFs to measure fracture severity and post-reduction contact stress exposure. This study is being conducted in collaboration with the University of Iowa PI Donald Anderson, PhD who is conducting these calculations on patients identified at the U.S. Army Institute of Surgical Research. IRB and HRPO approval has been obtained at both sites. Ongoing screening of potential subjects identified through the Department of Defense Trauma Registry has resulted in 58 subjects enrolled. Of these 42 subjects images have already been forwarded to U of Iowa for analysis. Our partners at the U of Iowa continue to work on related efforts in civilian trauma patients to refine the measuring techniques. The military subjects pose some unique challenges in terms of injury severity but we remain confident that our collaborators skill in imaging analysis will remain successful as we study our military patients.

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  • Medicine and Medical Research

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