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Prevention of Organ Injury in Exertional Heat Stroke: Preclinical Evaluation of a New Class of NSAIDs

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Technical Report,30 Sep 2015,29 Sep 2016

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University of Florida Gainesville United States

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In the first year we have completed a study of 128 adult male and female mice. Each mouse was exercise trained for a period of 3 weeks and then exposed to exertional heat stroke EHS, running on a forced running wheel in a 37.5 deg C35 RHG environmental chamber. Mice ran until they became unconscious core temperature of 42.2 deg C in both sexes, neurological symptoms and organ injury resembling human EHS. Blood and tissue samples were collected at 0.5 h, 3 h, 24 h 4d,9d and 14d of recovery. Heart tissue and plasma were submitted for metabolomic and lipidomic analysis awaiting results. Blood samples were submitted for cytokine analyses, metabolic hormone analyses and corticosteroids. Female mice were significantly more resistant to EHS, running longer, at higher running velocities and greater heat loads. Female mice had significantly higher levels of corticosterone 2 fold and greater levels of metabolic hormones associated with adipose tissue. Analyses of metabolic hormones and histology in both sexes suggest transient injury or stunning to the pancreas.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology
  • Pharmacology

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