Immune-Stimulating Combinatorial Therapy for Prostate Cancer
Technical Report,30 Sep 2015,29 Sep 2016
John Hopkins University Baltimore United States
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In this project we aim to demonstrate a proof-of-concept in an animal model that combined radiation therapy and magnetic nanoparticle hyperthermia can elicit an anti-cancer immune response to inhibit progression of prostate cancer tumors. During this reporting period we 1 established a suitable tumor model and methods for inducing tumor immunologic effects with magnetic iron oxide nanoparticle MION hyperthermia and external beam radiation therapy and, 2 developed methodologies that will be used to elucidate the role of key immune cell populations in tumors. Results obtained during this reporting period indicate that treatment of a model primary tumor by nanoparticle hyperthermia alone does not elicit a measurable response in a distal untreated tumor whereas radiation therapy alone generated a modest response in distal tumors. Interestingly, the combination of radiation hyperthermia produced the greatest observed distal tumor growth inhibition, and was associated with significantly elevated intratumor FOXP3, a master immune regulatory protein, levels. Radiation and hyperthermia single-agent therapies were associated with FOXP3 levels similar to untreated controls. These early results are encouraging and motivate further study.
- Medicine and Medical Research