Targeting Discoidin Domain Receptors in Prostate Cancer
Technical Report,01 Aug 2016,31 Jul 2017
Wayne State University Detroit United States
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We report the progress of our studies focusing on the Discoidin Domain Receptors DDRs, a set of kinase receptors that signal in response to collagen in prostate cancer. The projects goal is to define the expression and therapeutic potential of DDRs in prostate cancer. During the second funding period, we concluded the immunohistochemical study of DDR1 expression in a 200 case GradeStage tissue microarray TMA using a highly specific antibody. These studies described the localization of DDR1 in normal vs. tumor tissues and the association between staining intensity and Gleason score. We found that DDR1 expression may be an early indicator of PCa development. DDR1 is over-expressed in tumor tissues among the low Gleason score patients but not in the high Gleason score patients. We continued the studies to test a highly specific DDR1 blocking antibody Ab in intraosseous growth of human PC3 prostate cancer cells.
- Medicine and Medical Research
- Anatomy and Physiology