Accession Number:

AD1044336

Title:

Gestational Exposure to Soy Isoflavones and Epigenetic Regulation of Breast Cancer Risk

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

The University of Arizona Tucson United States

Personal Author(s):

• Romagnolo, Donato F.
• Selmin,Ornella I.

Report Date:

2016-10-01

Pagination or Media Count:

16.0

Abstract:

The overarching challenge is to identify what makes the breast susceptible to cancer development, and more specifically, the mechanisms that link epigenetic silencing of the BRCA-1 gene to the development of triple-negative breast cancers TNBC. The main purpose of this project is to examine whether the DNA methyltransferase DNMT inhibitor and soy isoflavone, genistein prevents CpG methylation of the BRCA-1 gene and development of TNBCs. Major findings Preliminary data acquired through the support of this grant indicate that 1 in cell culture experiments with ER-positive breast epithelial cells genistein exerted dose- and time dependent preventative effects on repression of BRCA-1 expression.

Descriptors:

• breast cancer
• epigenetics
• inhibitors
• phenols
• gene expression
• therapeutics
• cancer research

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE