Accession Number:
AD1043837
Title:
Controlling Mitochondrial Dynamics to Mitigate Noise-Induced Hearing Loss
Descriptive Note:
Technical Report,15 Sep 2016,14 Sep 2017
Corporate Author:
Oregon Health and Science University Portland United States
Personal Author(s):
Report Date:
2017-10-01
Pagination or Media Count:
18.0
Abstract:
In this study, we are examining the efficacy of a potential early intervention therapeutic for noise induced hearing loss NIHL. The generation of reactive oxygen species is one of the underlying mechanisms of noise-induced damage to tissues in the inner ear that leads to noise-induced hearing loss NIHL. The goal is to define an effective post-exposure, non-invasive intervention strategy to mitigate a primary cause of loud-sound induced hearing loss mitochondrial dysfunction and overproduction of reactive oxygen species. Utilizing a small molecule mitochondrial fission inhibitor, mitochondrial division inhibitor-1, the results so far have demonstrated that inhibition of the mitochondrial fission process significantly attenuates NIHL and reduces damage to the tissues of the inner ear resulting from a single acute sound exposure.
Descriptors:
Subject Categories:
- Medicine and Medical Research
- Anatomy and Physiology
- Biochemistry