Accession Number:

AD1043825

Title:

Advanced Development of Gamma-Tocotrienol as a Radiation Countermeasure

Descriptive Note:

Technical Report,21 Sep 2016,20 Sep 2017

Corporate Author:

Henry M. Jackson Foundation for the Advancement of Military Medicine Bethesda United States

Personal Author(s):

• Singh, Vijay K.

Report Date:

2017-10-01

Pagination or Media Count:

56.0

Abstract:

During the second year of the project, we completed all analyses for the pharmacokinetic study with gamma-tocotrienol GT3 in four NHPs. Specifically, we completed subtask 3, 4, and 5 of major task 1 and 2. PK analysis of GT3 serum revealed results consistent with that with a previous PK study conducted in the PIs lab with GT3 of DTRA project. In addition, subtask 1 of major task 3 was completed during this reporting period. We collected and analyzed samples for complete blood counts, blood biochemistry, cytokine profile, citrulline, flow cytometric phenotyping of hematopoietic cells and gastrointestinal studies. We have completed one cohort of subtask 2 and anticipate to begin a second cohort of NHPs in order to complete subtask 2 in the very near future. Overall, project is progressing well.

Descriptors:

• pharmacokinetics
• countermeasures
• sampling
• blood chemistry
• cytokines
• hematopoietic cells
• biological markers
• growth factors
• GASTROINTESTINAL DISEASES
• vitamin E
• assays
• Vital Signs
• histology
• intestines

Subject Categories:

• Medicine and Medical Research
• Pharmacology
• Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE