Accession Number:

AD1043779

Title:

Multifunctional PSCA antibody fragments for PET and optical prostate cancer imaging

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

University of California, Los Angeles Los Angeles United States

Personal Author(s):

Report Date:

2017-10-01

Pagination or Media Count:

11.0

Abstract:

The goals of this work are to develop engineered antibody fragments cys-diabodies and cys-minibodies for labeling with positron-emitting radionuclides and fluorescent dyes for multimodal imaging of prostate cancer. Previously, a novel cys-minibody recognizing PSCA prostate stem cell antigen was produced, conjugated, and radiolabeled with either I-124 or Zr-89. Targeting, imaging, and biodistribution studies in mouse models of prostate cancer confirmed excellent targeting and immunoPET imaging in PSCA-positive tumors in mice. This year, dual-labeling with radionuclide and fluorescent dye of the cys-minibody has been developed and evaluated in three different mouse models of prostate cancer. Furthermore, F-18 labeling has been established for a PSCA-specific cys-diabody and successfully imaged. A novel multifunctional linker has also been developed and dual F-18 PETNIR fluorescence imaging has been achieved.

Subject Categories:

  • Medicine and Medical Research
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE