Accession Number:

AD1043615

Title:

Protective Role of Angiogenin Against Hematopoietic Syndrome of the Acute Radiation Syndrome

Descriptive Note:

Technical Report,05 Aug 2015,04 Feb 2017

Corporate Author:

TUFTS-NEW ENGLAND MEDICAL CENTER BOSTON MA BOSTON

Personal Author(s):

• Hu, Guo-fu

Report Date:

2017-05-01

Pagination or Media Count:

282.0

Abstract:

We have fully documented the function of angiogenin ANG in protecting and mitigating damages caused by radiation exposure. We have examined the effect of ANG deficiency on HSPC, LymPro, MyePro, and found that ANG deficiency the number of HSPC, LymPro, and MyePro. We have also found that ANG deficiency resulted in more active cycling of HSPC and LymPro but restricted cycling of MyePro. As the consequence of ANG deficiency on hematopoietic cells, we found that ANG deficiency reduced animal survival upon exposure to radiation.

Descriptors:

• radiation damage
• RADIOPROTECTIVE AGENTS
• HEMATOPOIETIC CELLS
• PROGENITOR CELLS
• MYELOID CELLS

Subject Categories:

• Radiobiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE