Comprehensive Molecular Profiling of African-American Prostate Cancer to Inform on Prognosis and Disease Biology
Technical Report,30 Sep 2016,29 Sep 2017
University of Michigan Ann Arbor United States
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Epidemiological studies consistently show worse prostate cancer PCa incidence and mortality rates in African American AA vs. whiteCaucasian CA men. Although the etiology is likely multi-factorial, increasing evidence supports biologic contributors and AA PCa may arise through distinct pathways and harbor unique molecular alterations. We hypothesized that comprehensive molecular analysis of a carefully annotated AA PCa cohort including anatomical annotation will inform on the applicability of PCa prognostic signatures and identify novel drivers of aggressive disease in AA patients, thereby impacting the clinical management of AA patients and improving our understanding of the molecular events that underlie racial disparities in PCa behavior. Herein, using a large well annotated cohort of AA PCa, we are assessing the performance of prognostic gene expression signatures, and characterizing known and novel gene fusions, mutations and copy number alterations to develop novel prognostic signatures and assess the validity of commercially available signatures in AA men.
- Medicine and Medical Research