Accession Number:

AD1043294

Title:

Genetic and Diagnostic Biomarker Development in ASD Toddlers Using Resting State Functional MRI

Descriptive Note:

Technical Report,01 Sep 2014,31 Aug 2017

Corporate Author:

Yale University New Haven United States

Personal Author(s):

Report Date:

2017-11-01

Pagination or Media Count:

6.0

Abstract:

Our overarching strategy is to exploit three large neuroimagingneurobehavioral datasets to identify brain-imaging based biomarkers for Autism Spectrum Disorders ASD. At Yale, we focus on determining if brain networks are influenced by genetic factors and if these genetic factors also influence other traits associated with ASD. Specifically, we will provide heritability estimates and test for pleitropy between putative ASD functional and structural networks and cognitive and behavioral traits. Further, we examined the impact of non-synonymous protein coding genetic variants on these ASD connectivity traits.

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE