Accession Number:

AD1043141

Title:

Toward a Molecular Understanding of Noise-Induced Hearing Loss

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

University of Maryland Baltimore United States

Personal Author(s):

• Hertzano, Ronna

Report Date:

2017-10-01

Pagination or Media Count:

12.0

Abstract:

The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have a Established the hair cell HC and supporting SC cell-specific translatome of adult mouse inner ears b Established the molecular changes induced by PTS-resulting noise exposure in HC, SC and whole inner ears, 6 and 24 hours after noise exposure and began the TTS analysis c We identified critical differences in the response of male and female mice to noise, and obtained approval to modify Specific Aim 3 to focus on the response to Heat Shock profiling male and female mice, separately.

Descriptors:

• gene expression
• NOISE
• exposure (physiology)
• EAR

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology
• Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE