Accession Number:

AD1043110

Title:

Use of Topical PC-NSAIDs to Treat Burn Injury and Pain

Descriptive Note:

Technical Report,05 Jul 2014,04 Jul 2017

Corporate Author:

University of Texas Health Science Center at Houston Houston United States

Personal Author(s):

• Lichtenberger, Lenard M.

Report Date:

2017-10-01

Pagination or Media Count:

17.0

Abstract:

Studies have shown that the rat dorsal skin and hind limb burn injury models of 2nd degree burns are appropriate for testing the analgesic and healing rate efficacy of test drugs. These models were used to test Ibuprofen Ibu, Ibuprofen associated with phosphatidylcholine Ibu-PC, Indomethacin Indo, and Indo-PC. The experimental drug Indo-PC showed analgesic and anti-inflammatory efficacy over Indo alone or the Ibu drugs, notably when administered parenterally without notable side-effects. These studies support a rationale for continued development of parenteral Indo-PC for treatment of 2nd degree burn wounds.

Descriptors:

• burns
• ANTI INFLAMMATORY AGENTS
• drugs
• pain
• inflammation
• toxicity
• models

Subject Categories:

• Pharmacology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE