Accession Number:

AD1043051

Title:

Mathematical Model of HIF-1 alpha Pathway, Oxygen Transport and Hypoxia

Descriptive Note:

Technical Report,01 Oct 2016,01 Sep 2017

Corporate Author:

Henry M. Jackson Foundation For the Advancement of Military Medicine Wright-Patterson AFB

Personal Author(s):

• Robinson,Peter J.
• Hack,C. E.
• Merrill,Elaine A.
• Mattie,David R.

Report Date:

2017-09-01

Pagination or Media Count:

49.0

Abstract:

Episodes of hypoxia-like events experienced by F-22 pilots after training missions have raised questions about pilot exposures and diminished operational mission accomplishment. These episodes identified data gaps in the understanding of pilot exposures in high performance aircraft. We, therefore, need to understand how levels of low oxygen at lower than atmospheric pressure causes physiological hypoxia, and how this relates to alterations in cognition. Oxygen sensing pathways, particularly those involving the oxygen sensing cytosolic gene transcription factor HIF-1, are key to understanding these responses. A mathematical model was developed to integrate these experimental measurements and provide a description of hypoxia mechanisms and the organisms response.

Descriptors:

• CEREBRAL HYPOXIA
• sensory receptor cells
• proteins
• neurons
• cellular structures
• microvessels
• experimental data
• gene expression
• high altitude
• mathematical models
• body fluids
• cardiovascular physiological processes
• transcription factors
• PILOTS
• FIGHTER AIRCRAFT
• EXPOSURE (Physiology)
• flight training
• stress (physiology)
• military medicine

Subject Categories:

• Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE