The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy
Technical Report,08 Sep 2016,07 Sep 2017
Wake Forest University Health Sciences Winston Salem United States
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The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in the regulation of tumor dormancy. Aim1 will identify and explore how disseminated tumor cells DTCs stay dormant for longperiods of time. We postulate that DTCs drive the bone marrow niche into dormancy through the GAS6 pathway. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. During this period, we found that a fast growing less differentiated osteoblast may contribute to growth of bone metastatic prostate cancer. In addition, we developed a new and creative in vitro cell culture system that allows us to evaluate the effects of osteoblastic activation on the growth of disseminated prostate cancer cells.
- Medicine and Medical Research