Accession Number:

AD1042929

Title:

The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy

Descriptive Note:

Technical Report,08 Sep 2016,07 Sep 2017

Corporate Author:

Wake Forest University Health Sciences Winston Salem United States

Personal Author(s):

Report Date:

2017-10-01

Pagination or Media Count:

73.0

Abstract:

The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in the regulation of tumor dormancy. Aim1 will identify and explore how disseminated tumor cells DTCs stay dormant for longperiods of time. We postulate that DTCs drive the bone marrow niche into dormancy through the GAS6 pathway. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. During this period, we found that a fast growing less differentiated osteoblast may contribute to growth of bone metastatic prostate cancer. In addition, we developed a new and creative in vitro cell culture system that allows us to evaluate the effects of osteoblastic activation on the growth of disseminated prostate cancer cells.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE