PDI Coamplified Genes in Ovarian Cancer
Technical Report,01 Jun 2014,31 May 2017
University of Michigan Ann Arbor United States
Pagination or Media Count:
Epithelial ovarian cancers EOCs are a heterogeneous group of tumors with distinct subtypes having different tissues of origin, diverse genetic landscapes, and respond differently to therapy.1-3 For example, serous EOC is thought to originate in the distal fallopian tube4 whereas ovarian clear cell carcinomasOCCCs originate from endometriotic tissues.5 While mutations in p53 are uncommon in OCCCs 9-10 they are common in serous EOC 96.6 OCCCs are usually classified as high-grade carcinomas, and were considered a uniform entity. However, recent studies have revealed that OCCCs are genetically heterogeneous and can be further subdivided into distinct categories.7 In the United States, OCCCs account for 5-13 of all EOCs, whereas in Japan they account for 15-25. OCCCs are associated with poorer prognosis and are frequently resistant to conventional platinum-based chemotherapy. We hypothesize that subgroups of EOC harbour specific genetic alterations that ultimately override the apoptotic machinery to render them more chemoresistant than other EOCs. Such genetic alterations are best studied in a broad panel of samples from different ethnicities.
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