Contribution of p75NTR to Schwannoma Growth and Therapeutic Responses
Technical Report,01 May 2016,30 Apr 2017
University of Iowa Iowa City United States
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We find that the NF2 gene product, merlin, regulates p75NTR expression levels and signaling. This depends on the phosphorylation state of merlin. We also find that activation of p75NTR fails to induce apoptosis in SCs and schwannoma cells that lack functional merlin expression, in contrast to normal SCs. Further, activation of p75NTR in human VS cells protects the cells from some forms of cell death.
- Medicine and Medical Research