Human Cell Line Activation Test of the Novel Energetics 2,6-pyrazinediamine 3,5-dinitro 1 -oxide (LLM-105) and 2,4,6-trinitro-3-bromoanisole (TNBA)
Technical Report,01 Jan 2017,01 Nov 2017
Army Public Health Center Aberdeen Proving Ground United States
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The energetic and toxicological properties of 2,6-pyrazinediamine 3,5-dinitro-1 -oxide LLM-105 and 2,4,6-trinitro-3-bromoanisole TNBA are being determined to support an evaluation of LLM-105 and TNBA as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine RDX and trinitrotoluene TNT. This study assessed the skin sensitization potential of LLM-105 and TNBA through the human cell line activation test h-CLAT, an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the induction of a skin allergy. Both compounds induced a positive response in the assay.