Human Cell Line Activation Test of the Novel Energetics Methyl Trinitropryrazol (MTNP) and 1,3-Dimethylhexahydropyrimidine (DHP)
Technical Report,01 Jan 2017,01 Nov 2017
Army Public Health Center Aberdeen Proving Ground United States
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The energetic and toxicological properties of methyl trinitropyrazol MTNP and 1,3-dimethylhexahydropyrimidine DHP are being determined to support an evaluation of these compounds as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine RDX and trinitrotoluene TNT. This study assessed the skin sensitization potential of MTNP and DHP through the human cell line activation test h-CLAT, an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the induction of a skin allergy. MTNP induced a positive reaction in the assay, while DHP did not.