Accession Number:

AD1042152

Title:

Human Cell Line Activation Test of the Novel Energetics Methyl Trinitropryrazol (MTNP) and 1,3-Dimethylhexahydropyrimidine (DHP)

Descriptive Note:

Technical Report,01 Jan 2017,01 Nov 2017

Corporate Author:

Army Public Health Center Aberdeen Proving Ground United States

Personal Author(s):

Report Date:

2017-11-01

Pagination or Media Count:

31.0

Abstract:

The energetic and toxicological properties of methyl trinitropyrazol MTNP and 1,3-dimethylhexahydropyrimidine DHP are being determined to support an evaluation of these compounds as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine RDX and trinitrotoluene TNT. This study assessed the skin sensitization potential of MTNP and DHP through the human cell line activation test h-CLAT, an in vitro approach to assess dendritic cell activation by chemicals, a critical step in the induction of a skin allergy. MTNP induced a positive reaction in the assay, while DHP did not.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE