Rescue of TET2 Haploinsufficiency in Myelodysplastic Syndrome Patients Using Turbo Cosubstrate
Technical Report,20 Jun 2016,19 Jun 2017
University of Missouri System Kansas City United States
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During this period, we have demonstrated that 2-oxoglutarate 2OG analogs can dramatically enhance the activity of TET2 enzymes from MDS patient. Further, we published a manuscript on convenient expression, purification and quantitative liquid chromatography-tandem mass spectrometry-based analysis of TET2. Finally, we have identified novel substrate specificity of TET2 oxygenase.
- Medicine and Medical Research