Accession Number:

AD1041555

Title:

Rescue of TET2 Haploinsufficiency in Myelodysplastic Syndrome Patients Using Turbo Cosubstrate

Descriptive Note:

Technical Report,20 Jun 2016,19 Jun 2017

Corporate Author:

University of Missouri System Kansas City United States

Personal Author(s):

• Mukherji, Mridul

Report Date:

2017-07-01

Pagination or Media Count:

18.0

Abstract:

During this period, we have demonstrated that 2-oxoglutarate 2OG analogs can dramatically enhance the activity of TET2 enzymes from MDS patient. Further, we published a manuscript on convenient expression, purification and quantitative liquid chromatography-tandem mass spectrometry-based analysis of TET2. Finally, we have identified novel substrate specificity of TET2 oxygenase.

Descriptors:

• liquid chromatography
• mass spectrometry
• substrate specificity
• cell line
• chromatography
• hematologic diseases
• substrates
• crystal structure
• lymphatic diseases
• culture techniques
• mutations
• neoplasms
• biological processes
• biomedical research
• gene expression
• patients
• mutations

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE