Accession Number:

AD1041425

Title:

Vision Integrating Strategies in Ophthalmology and Neurochemistry (VISION)

Descriptive Note:

Technical Report,28 Feb 2015,27 May 2016

Corporate Author:

University of North Texas Health Science Fort Worth United States

Personal Author(s):

• Yorio, Thomas
• Clark,Abbot

Report Date:

2016-08-01

Pagination or Media Count:

16.0

Abstract:

The overall goal of the VISION project is to discover neuroprotective strategies in three separate mouse models of injury to the visual axis, in order to identify potential candidates for the treatment of combat eye injuries and preserve vision in our injured warfighters. We have established three different mouse models of ocular injury with different injury- initiating mechanisms i.e. optic nerve crush, retinal ischemiareperfusion, and chronic ocular hypertension. We have developed techniques to quantify damage to the retina, optic nerve, and visual axis in the brain i.e. superior colliculus that are damaged in these three models.

Descriptors:

• therapeutics
• ophthalmology
• retinal diseases
• BRAIN INJURIES
• NEUROPROTECTIVE DRUGS
• transcription factors
• nervous system

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE