Modification of Acute Radiation Response in Different Demographic Age Groups
Applied Research Associates Arlington United States
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Accurate casualty estimation tools are critical in preparedness and response planning for nuclear and radiological scenarios. Current consequence assessment models are based on healthy adult males and may not adequately represent the entirety of an affected population. The focus of the current work was to review data on the variability in response to radiation among different ages at exposure. A significant amount of animal data was categorized by age groups corresponding to physiological and developmental stages and extrapolated to humans. Using the LD50 response in adult animals as the reference, the LD50 values from other age groups were used to obtain a dose modification factor DMF for non-adult age groups. The overall trend observed in the animal work was an increase in radiosensitivity among younger and older animals. The average DMF values for each category were used to extrapolate and modify the adult LD50 to estimate dose response relationships DRRs for different age categories in humans. The DRRs may be integrated into casualty estimation tools for population-based scenario analyses.