Technique Development Results for the Study of a Novel Dexamethasone Impregnated Bandage Contact Lens in a Rabbit Model After Photorefractive Keratectomy
59th Medical Wing San Antonio United States
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Introduction Many conditions can lead to ophthalmic inflammation, which can become painful and blinding. Steroid eye drops are the most common treatment and compliance is often acomplicating issue. In attempts to alleviate compliance errors, experimental contact lenses impregnated with steroids are now being produced. This study is investigating an experimental dexarnethasone-eluting contact lens.Methods Thirty-five New Zealand White rabbits were approved for use in the technique development stage and in four different study arms. The technique development stage had different refractive surgery procedures, tarsorrhaphy configurations, and nictitating membranecon figurations to determine the best surgical combination for study results. The first study arm included the experimental contact lens replaced weekly, a second arm with a bandage contact lens replaced weekly, a third arm with a bandage contact lens only the first week, and a fourth arm with no bandage contact lens at any point. The non-experimental contact lens arms received dexamethasone drops. The left eye served as control.
- Medicine and Medical Research