Antifungal Resistance Patterns in Molds Isolated from Wounds of Combat Related Trauma Patients
59th Medical Wing San Antonio United States
Pagination or Media Count:
Background An outbreak of trauma-related invasive fungal infections IFI occurred in US service members injured in Afghanistan. Empiric treatment included voriconazole VORl and amphotericin AMB and aggressive surgical debridement. Antifungal susceptibilities AS and relation to outcoID Week, San Diego, CA, Oct 5 2017mes are yet to be described. Methods Between 2009-2013, military trauma patients with initial unique and serial 3 days after initial isolation molds isolated from wounds and admitted to Brooke Anny Medical Center as part of the Trauma Infectious Disease Outcomes Study were assessed. The AS to AMB, VORI, posaconazole POSA, isavuconazole ISA, itraconazole, and caspofungin were determined by broth microdilution with CLSI breakpoint interpretations for Aspergillus spp. and mucormycetes MM. Results Included are 18 patients with 28 initial mold isolates with 72 of lFI diagnosed via histopathology. All patients were male with a median of 8 operations. There was a median of 11 days post-injury to mold culture.
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