Accession Number:

AD1040216

Title:

Auer Rod Formation in Mature Eosinophils is an Extremely Rare Manifestation of Myelodysplasia

Descriptive Note:

Technical Report

Corporate Author:

AIR FORCE MEDICAL WING (59TH) WILFORD HALL AMBULATORY SURGICAL CENTER LACKLAND AFB United States

Personal Author(s):

Report Date:

2017-08-08

Pagination or Media Count:

3.0

Abstract:

A 50-year-old woman was discovered to have incidental mild leukocytopenia and thrombocytopenia. Rare blasts and dysplastic neutrophils were seen on peripheral blood smear. A bone marrow examination revealed dysplastic granulocytes and megakaryocytes with 1 blasts. Cytogenetic testing demonstrated a complex karyotype including del5q. A diagnosis of refractory cytopenia with multilineage dysplasia was rendered 2008 WHO. Her bone marrow blast count subsequently increased to 10 and she underwent an allogeneic peripheral blood stem cell transplant. She was doing well however, one year post-transplant, a bone marrow biopsy again showed 10 blasts and dysplastic myeloid cells, including rare dysplastic eosinophils with Auer rod-like bodies, consistent with recurrent high grade myeloid malignancy.

Subject Categories:

  • Medicine and Medical Research
  • Medicine and Medical Research
  • Medicine and Medical Research
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE