Pupillometry and Saccades as Objective mTBI Biomark
Technical Report,30 Sep 2014,29 Mar 2017
The Geneva Foundation TACOMA United States
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The objective of the study is to validate pupillary light reflex PLR, saccadic and convergence eye movements as objective biomarkers for the identification of Warfighters with acute mild traumatic brain injury mTBI using commercial-off-the-shelf COTS instruments infrared pupillometers, King-Devick KD test and near point of convergence NPC rule,respectively. Hundred mTBI and 100 age-matched non-TBI controls military personnel were recruited from the patient population at Womack Army Medical Center WAMC. This study was designed to determine within each group the effectiveness of these tests, individually andorin combination, to correctly identify mTBI in agreement with the mTBI diagnosis made by the WAMC Department of Brain Injury Medicine. Results showed that three of the eight PLR parameters are statistically different between the groups average constriction velocity, average dilation velocity, and 75 dilation recovery time. In addition, the KD test, NPCrule, and the CISS survey showed sensitivity in identifying military personnel with mTBI.
- Medicine and Medical Research
- Military Forces and Organizations