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Genetic Alterations in Prostate Cancers among African American Men and Comparisons with Cancers from European and Asian Patients

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Technical Report,29 Sep 2015,28 Sep 2016

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NorthShore University HealthSystem Evanston United States

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A large and systematic evaluation of somatically acquired changes in the tumors of African American man is needed to identify race-specific signatures that may be associated with increased aggressive and poor outcome of prostate cancer PCa in this under-studied population. We have analyzed DNA copy number alterations CNAs in a subset of the tumors from African Americans with PCa and compared them to those in European American and Chinese PCa. Our data reveal that the most frequent CNAs include hemizygous deletions on chromosomal 8p and 13q represented by BNIP3L and RB1, respectively. To our surprise, no subjects in this subset of African American patients harbored the deletion between the 3 of TMPRSS2 and 3 ERG TE that creates the fusion of these two genes. Preliminary result analysis suggests that the tumor genome of African American PCa may harbor a distinct CNA landscape, though analyzing a large number of tumors from additional patients is warranted to confirm our findings. In addition, we have developed a multiplex ligation-dependent probe amplification MLPA-based method and a probe mix panel for identifying PTEN deletions and MYC amplifications that have been shown to be associated with lethal PCa. Additional experiments are needed to demonstrate the utility of this probemix for the identification of patients with aggressive PCa in African Americans.

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology

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