Marrow Derived Antibody Library for the Treatment of Neuroblastoma
Technical Report,01 Sep 2012,30 Sep 2015
SPECTRUM HEALTH SYSTEM GRAND RAPIDS United States
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Neuroblastoma NB is the most common solid tumor in children, which accounts for 15 of all pediatric cancer deaths in the US. New therapeutic antibodies to treat NB are urgently needed to improve survival. The purpose of this project is to produce patient-specific therapeutic antibodies to treat neuroblastoma. The goal is to develop new methods and strategies to capture the auto-immune response reaction in neuroblastoma patients using phage display and B cell hybridoma technologies. The scope of this project is to use NB patient-derived materials to create NB cell lines, xenograft models, NB specific phage display libraries and to identify and amplify functional anti-NB specific antibodies for future therapeutic intent.
- Medicine and Medical Research