Accession Number:

AD1039600

Title:

Marrow Derived Antibody Library for the Treatment of Neuroblastoma

Descriptive Note:

Technical Report,01 Sep 2012,30 Sep 2015

Corporate Author:

SPECTRUM HEALTH SYSTEM GRAND RAPIDS United States

Personal Author(s):

• Saulnier Sholler,Giselle

Report Date:

2015-12-01

Pagination or Media Count:

16.0

Abstract:

Neuroblastoma NB is the most common solid tumor in children, which accounts for 15 of all pediatric cancer deaths in the US. New therapeutic antibodies to treat NB are urgently needed to improve survival. The purpose of this project is to produce patient-specific therapeutic antibodies to treat neuroblastoma. The goal is to develop new methods and strategies to capture the auto-immune response reaction in neuroblastoma patients using phage display and B cell hybridoma technologies. The scope of this project is to use NB patient-derived materials to create NB cell lines, xenograft models, NB specific phage display libraries and to identify and amplify functional anti-NB specific antibodies for future therapeutic intent.

Descriptors:

• biological staining and labeling
• bacterial infections
• histological techniques
• confocal microscopy
• cell membrane
• amino acids
• therapeutics
• surgical procedures
• neuroblastoma
• neoplasms
• antibodies
• lymphatic system
• bone marrow
• ANTIBODIES

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE