Accession Number:

AD1039581

Title:

Poloamer 188 as an Adjunct in Prolonged Hypotensive Resucitation

Descriptive Note:

Technical Report,01 Jul 2006,30 Jun 2007

Corporate Author:

The University of Texas Health Science Center at Houston Houston United States

Personal Author(s):

• Hunter,Robert
• Moore,Frederick
• Gonzalez,Ernest
• Zhang,Rongzhen

Report Date:

2017-07-01

Pagination or Media Count:

7.0

Abstract:

Despite tremendous efforts, exsanguinations remains a leading cause of deaths approximately 40 in both civilian and military trauma. A subset of injured soldiers develop decompensated shock that requires early interventions if they are to survive. This project is testing the ability of a new drug, purified poloxamer 188 P188, to increase survival and reduce inflammation and organ injury resulting from prolonged periods of hypotensive resuscitation in a model specified by the ARMY. The results are strongly positive. Addition of P188 to standard therapy with Hextend significantly improved survival p0.002and reduced fluid requirements p0.0002 in rats subjected to prolonged hypotensive resuscitation. These studies are being followed up with studies with more complex injuries and with uncontrolled hemorrhage in rats, rabbits and pigs.

Descriptors:

• drug therapy
• hypotension
• inflammation
• survivability
• cardiovascular physiological phenomena
• hemorrhagic shock
• resuscitation
• symptoms and general pathology
• pathologic processes
• hypovolemia
• infusions
• heart rate
• laboratory animals
• copolymers

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE