Accession Number:

AD1039576

Title:

Targeting Signaling to YAP for the Therapy of NF2

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2016

Corporate Author:

Memorial Sloan Kettering Cancer Center New York United States

Personal Author(s):

• Giancotti,Filippo G.

Report Date:

2016-12-01

Pagination or Media Count:

11.0

Abstract:

The goals of this project are to utilize our new knowledge of the mechanism by which loss of Merlin induces tumorigenesis to identify small molecule compounds that block YAPTEAD-dependent transcription by acting at any step of our newly identified pathway, and to test the preclinical efficacy of lead compounds in xenograft models of NF2. During this grant, we have generated NF2 mutant cell lines expressing two different types of YAP reporters and tested their suitability for high throughput screening.

Descriptors:

• cell physiological processes
• confocal microscopy
• neoplasms
• cell membrane
• inhibition
• proteins
• epithelial cells
• nervous system
• TUMOR CELL LINE

Subject Categories:

• Medicine and Medical Research
• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE