Accession Number:

AD1039458

Title:

Stress Altered Stem Cells with Decellularized Allograft to Improve Rate of Nerve Regeneration

Descriptive Note:

Technical Report,10 Sep 2013,09 Sep 2015

Corporate Author:

Brigham and Women's Hospital Boston United States

Personal Author(s):

• Vacanti,Charles A

Report Date:

2015-12-01

Pagination or Media Count:

18.0

Abstract:

The research detailed in this final report is to study how to improve the rate of peripheral nerve regeneration. The slow rate of nerve regeneration in limbs results in poor prognosis for patients suffering from severe injuries, leading to muscle impairment, and in extreme cases, atrophy. For our research, we will study the rate at which nerves regenerate in a rat model. We will excise the peripheral nerve, and study how to modulate the nerve regeneration through the use of a decellularized nerve graft and stress altered cells SACs, a cell type we have identified that show stem--cell like qualities after undergoing physical and chemical stresses.

Descriptors:

• stem cells
• embryonic structures
• peripheral nervous system
• lymphocytes
• fibroblasts
• cells (biology)
• therapeutics
• regenerative medicine
• wounds and injuries

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE