Accession Number:

AD1039392

Title:

Positioning Vascularized Composite Allotransplantation in the Spectrum of Transplantation

Descriptive Note:

Technical Report,15 Sep 2015,14 Sep 2016

Corporate Author:

Childrens Hospital of Philadelphia Philadelphia United States

Personal Author(s):

• Hancock,Wayne W.

Report Date:

2016-10-01

Pagination or Media Count:

13.0

Abstract:

We have continued our studies of the immune mechanisms contributing to rejection of vascularized composite allografts VCA in murine models, and how these may be overcome to promote long-term allograft survival. We have now firmly established an orthotopic hind limb VCA model in our lab, and using this orthotopic model, have shown that either of 2 protocols, namely costimulation blockade CD40L monoclonal antibody plus 2 weeks of rapamycin, RPM, or anti-TCR monoclonal antibody plus 2 weeks of RPM, can each achieve long-term VCA survival without maintenance immunosuppression. We are currently using these approaches to explore mechanistic details. Lastly, we have begun to test whether HDAC targeting may have effects on the VCA survival.

Descriptors:

• Tolerance
• transplants
• Transplantation
• rejection
• therapeutics

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE