Accession Number:

AD1039362

Title:

Psychosocial Stress and Ovarian Cancer Risk: Metabolomics and Perceived Stress

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

Brigham and Women's Hospital Boston United States

Personal Author(s):

• Poole,Elizabeth

Report Date:

2016-10-01

Pagination or Media Count:

7.0

Abstract:

Mouse models suggest that chronic stress promotes ovarian tumorigenesis, but the relationship between stress and ovarian cancer has never been evaluated in humans. Over the last year of the grant, we published an analysis demonstrating that exposure to chronic stress leads to tumors that express the beta-2 adrenergic receptor, the signaling pathway identified in mouse models. We have also made progress developing a metabolomic signature of post-traumatic stress disorder PTSD, a sentinel chronic stress condition. Overall, our continuing work on the role of stress in ovarian cancer development indicates that chronic stress may increase risk of developing ovarian cancer.

Descriptors:

• ovarian cancer
• Stress (Psychology)
• DEPRESSIVE DISORDER
• anxiety
• metabolomics

Subject Categories:

• Medicine and Medical Research
• Psychology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE