Novel Therapy for Bone Regeneration in Large Segmental Defects
Technical Report,30 Sep 2015,29 Sep 2016
INDIANA UNIVERSITY INDIANAPOLIS United States
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The purpose of this study is to test the efficacy of thrombopoietin TPO to heal a segmental bone defect SBD in a large animal model, the minipig. The scope of the research comprises the following specific aims i to determine the union rate of tibial midshaft defects in minipigs treated with BMP-2, TPO, or saline control and ii to evaluate the safety and side effects of treating tibial midshaft defects in minipigs treated with BMP-2, TPO, or saline control. In the previous research periods we completed surgeries and collection of tissuedata from 27 minipigs which had surgeries with IM nail fixation and 12 minipigs which had surgeries with compression plate fixation. Perhaps the two most significant findings during this period are that we discovered that fixation type IM nail vs. compression plates impacts the size requirement for a critical size defect, and that even with a large segmental defect, that is not of critical size, TPO is able to more rapidly allow for bone healing than observed in saline treated controls. We believe with creating a large defect but with using compression plate fixation we can even further improve TPOs efficacy, which along with finalizing data collection from the previous pig surgeries, will be the main goals in our 1 year no cost extension period Year 4.
- Anatomy and Physiology