Microenvironment -Programmed Metastatic Prostate Cancer Stem Cells (mPCSCs)
Technical Report,13 Sep 2015,12 Sep 2016
University of Texas MD Anderson Cancer Center Houston United States
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Prostate cancer PCa metastasis represents the worst outcome that eventually kills the patient. Although many PCa cell-intrinsic molecules and end-organ factors have been implicated in the metastatic dissemination of PCa cells, the role of primary tumor microenvironment and the nature of the metastatic PCa cells remain poorly defined. By establishing a reliable and quantifiable experimental PCa metastasis model in NODSCID mice, we have found that PCa cells implanted orthotopically i.e., in the prostate metastasize much more extensively and widely than those implanted ectopically i.e., subcutaneously or s.c. Microarray-based gene expression profiling reveals that the orthotopically implanted human PCa cells upregulate several classes of genes that have been intimately implicated in metastasis.
- Medicine and Medical Research