Accession Number:



Closed Loop Control of Oxygen Delivery and Oxygen Generation

Descriptive Note:

Technical Report,01 May 2012,01 May 2017

Corporate Author:

University of Cincinnati Cincinnati United States

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Maintenance of adequate oxygenation and prevention of hypoxemia are the primary goals for the battlefield casualty, but in military operations, oxygen is a limited resource to be conserved. A portable oxygen concentrator has the advantage of operating solely from electrical power and therefore is a never-exhausting supply of oxygen. Our previous bench work demonstrated that the pulsed dose setting of the concentrator can be used in concert with the ventilator to maximize oxygen delivery. We evaluated this ventilator concentrator system with closed loop control of oxygen output in a porcine model. The Zoll 731 portable ventilator and Sequal Saros portable oxygen concentrator were used for this study and were connected via a USB cable to allow communication. The ventilator was modified to allow closed loop control of oxygen based on the oxygen saturation SpO2 via the integral pulse oximetry sensor. Twelve pigs were used for the evaluation. The animals were placed on a ventilator on 100 fraction of inspired oxygen FIO2 and lung injury was induced by warmed saline lavage via the endotracheal tube until partial pressure of oxygen PaO2FIO2 decreased to 100. The pigs were then placed on the ventilatorconcentrator system and allowed to adjust the oxygen autonomously to determine if the target SpO2 could be maintained.

Subject Categories:

  • Anatomy and Physiology

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