Accession Number:

AD1038409

Title:

Reconstructing Cell Lineages from Single-Cell Gene Expression Data: A Pilot Study

Descriptive Note:

Technical Report,01 Jul 2014,31 Mar 2015

Corporate Author:

Dana-Farber Cancer Institute, Inc. Boston United States

Personal Author(s):

• Yuan,Guo-Cheng

Report Date:

2016-08-30

Pagination or Media Count:

8.0

Abstract:

The goal of this pilot study is to develop novel mathematical methods, by leveraging tools developed in the bifurcation theory, to infer the underlying cell-state dynamics from single-cell gene expression data. Our proposed method contains two steps. The first step is to reconstruct the temporal order of the cells from gene expression data, whereas the second step is to model the dynamic changes of gene expression patterns. The tools developed here will be useful for reconstruct developmental trajectories from single-cell gene expression data.

Descriptors:

• GENE EXPRESSION
• GENOMICS
• Computational Biology
• BIRUFICATION (MATHEMATICS)
• erythroid cells
• chromosome structures
• transcription factors
• cell line

Subject Categories:

• Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE