Accession Number:

AD1037882

Title:

Impact of Juvenile Cannabinoid Receptor Targeting on Adult Restrictive-Repetitive Behaviors and Cytokine Expression

Descriptive Note:

Conference Paper

Corporate Author:

59th Medical Wing San Antonio United States

Report Date:

2017-11-11

Pagination or Media Count:

6.0

Abstract:

Restrictive-repetitive behavior are a core autism symptom that can be modeled in mice for behavioral pharmacology studies.. Marble burying is an index of repetitive behavior that is sensitive to sedatives. In prior studies WIN55,212-2 0.1 mgkg, a cannabinoid receptor CB1 and CB2 agonist, attenuated burying. Yet marble burying captures only lower order repetition, paralleling stereotopies like repetitive movements or manipulation of objects. To examine higher order restrictive perseverative behaviors such as insistence on sameness narrow interests, cognitive flexibility or reversal learning tests provide more insight.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE