Impact of Juvenile Cannabinoid Receptor Targeting on Adult Restrictive-Repetitive Behaviors and Cytokine Expression
59th Medical Wing San Antonio United States
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Restrictive-repetitive behavior are a core autism symptom that can be modeled in mice for behavioral pharmacology studies.. Marble burying is an index of repetitive behavior that is sensitive to sedatives. In prior studies WIN55,212-2 0.1 mgkg, a cannabinoid receptor CB1 and CB2 agonist, attenuated burying. Yet marble burying captures only lower order repetition, paralleling stereotopies like repetitive movements or manipulation of objects. To examine higher order restrictive perseverative behaviors such as insistence on sameness narrow interests, cognitive flexibility or reversal learning tests provide more insight.
- Medicine and Medical Research