Self-Regulation of the Primary Auditory Cortex Attention Via Directed Attention Mediated By Real Time fMRI Neurofeedback
59th Medical Wing San Antonio United States
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10 healthy volunteers with normal hearing no more than 1 frequency 40 dB on a standard audiogram underwent 5 fMRI-NFT sessions. Each session was composed of a simple auditory fMRI followed by 2 runs of Al fMRI-NFT. FMRI data was acquired using 2D, single-shot echo planar imaging during all 3 runs using a 3T. The auditory fMRI was comprised of 6 blocks, each containing a 20s period of no auditory stimulation followed by a 20s period of white noise stimulation at 90 dB. Al activity, defined from a region using the activity during the preceding auditory run, was continuously updated during fMRI-NFT using a simple bar plot, and was accompanied by white noise 90 dB stimulation for the duration of the scan. Each fMRI-NFT run contained 8 blocks, each separated into a 30s relax period followed by a 30s lower period. Subjects were instructed to watch the bar during the relax condition and actively lower the bar by decreasing A 1 activity during the lower condition. The average A 1 activity was measured from the simple auditory task from each session. Average A 1 deactivation was extracted from each fMRI-NFT run, representative of A 1 self-regulation performance.
- Anatomy and Physiology
- Medicine and Medical Research