The Development of Nitroxide Based Coatings for Biofilm Remediation- 154020
Technical Report,08 Sep 2015,07 Mar 2017
QUEENSLAND UNIVERSITY OF TECHNOLOGY Brisbane Australia
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In this research, the PI initially aimed to investigate the chemistry of nitroxides within biofilms in order to understand the mechanism by which nitroxides inhibit and disperse biofilms. The PIs then planned to develop new anti-biofilm agents based on nitroxides, explore the application of new chemistries for the immobilisation of nitroxides to relevant substrates and evaluate the effects of these function alised scaffolds on biofilm growth. The PI have synthesized a water soluble profluorescent nitroxide for biofilm imaging. This nitroxide was shown to eradicate an existing biofilm in conjunction with antibiotic use, with excellent results, indicating that these compounds are good targets for future research. Additional research shows that the surface binding nitroxides are most likely inactive, suggesting that the anti-biofilm actions is intracellular. The research resulted in 1 peer reviewed publication, 3 conference presentations, and 1 manuscript in progress. They also have an excellent collaboration with AFRLRX Wendy Goodson and will continue to work on testing compounds provided by this research.