Accession Number:

AD1037367

Title:

Advancements in DNA Vaccine Vectors, Non-Mechanical Delivery Methods and Molecular Adjuvants to Increase Immunogenicity

Descriptive Note:

Journal Article - Open Access

Corporate Author:

USAMRIID Ft Detrick United States

Report Date:

2017-06-15

Pagination or Media Count:

35.0

Abstract:

A major advantage of DNA vaccination is the ability to induce both humoral and cellular immune responses. DNA vaccines are currently used in veterinary medicine, but have not achieved widespread acceptance for use in humans due to their low immunogenicity in early clinical studies. However, recent clinical data have re-established the value of DNA vaccines, particularly in priming high-level antigen-specific antibody responses. Several approaches have been investigated for improving DNA vaccine efficacy, including advancements in DNA vaccine vector design, the inclusion of genetically engineered cytokine adjuvants, and novel non- mechanical delivery methods. These strategies

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE