Recovery of Breathing and Forelimb Function after Prolonged Exposure to Repetitive Acute Intermittent Hypoxia
Technical Report,01 Mar 2016,28 Feb 2017
University of Florida Gainesville United States
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The fundamental goal of this project is to test the efficacy and safety of prolonged repetitive exposure to acute intermittent hypoxia rAIH 10 episodes per day, 3 to 4 days per week, 3 to 6 months in a rodent model of chronic, incomplete cervical spinal injury C2 spinal hemisection in rats C2HS. In this collaborative project Florida and Saskatoon, Canada, we are exploring the impact of prolonged rAIH on both respiratory Florida and limb function Canada, and on markers of neuro-cognitive and cardiovascular safety Florida. Three specific aims were proposed Aim 1 Test the hypothesis that prolonged rAIH elicits robust and prolonged improvement of breathing capacity after chronic C2HS Aim 2 Test the hypothesis that prolonged rAIH in combination with task specific training elicits robust and prolonged improvement of voluntary forelimb function after chronic C2HS and Aim 3 Test the hypothesis that prolonged rAIH has no significant impact on hippocampal cell survival or systemic blood pressure. These pre-clinical studies are an essential next-step in our efforts to translate rAIH as a therapeutic modality to restore respiratory and non-respiratory motor function in patients with chronic, incomplete SCI.
- Medicine and Medical Research