Antibiotic Resistance In Neisseria Gonorrhoeae: Impact Of Ceftriaxone Resistance On Microbial Fitness And Potential Of Resistance Determinants To Spread During Mixed Infection
Uniformed Services University of the Health Sciences Bethesda United States
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Approximately 106 million cases of gonorrhea occur worldwide each year, and antibiotic treatment is critical for control. However, the rapid evolution of drug resistance in Neisseria gonorrhoeae Gc threatens this strategy. Extended-spectrum cephalosporins ESC, including ceftriaxone Cro, are the last remaining monotherapy for gonorrhea. Increasing resistance of Gc to the ESCs has amplified the threat of untreatable gonorrhea. Cro resistance in Gc is conferred primarily by mosaic penA alleles that encode multiple amino acid substitutions within penicillin-binding protein 2 PBP 2.