Hazard Assessment of High-Nitrogen Explosive Compounds: A Novel In Vitro Multi-Cellular Approach
Uniformed Services University of the Health Sciences Bethesda United States
Pagination or Media Count:
The energetic properties of high-nitrogen high-N content materials have increased the interest towards their development for use in insensitive munitions. However, the use of such compounds in the production of explosives is known to lead to an increased risk of adverse health effects in munition factory workers and the general population through various occupational and environmental exposure pathways. While chemical hazard assessment with live animals has many advantages, the high cost of in vivo testing, in terms of resource consumption, animal usage, and time, only allows for the testing of a limited number of compounds.