Accession Number:

AD1036855

Title:

Hazard Assessment of High-Nitrogen Explosive Compounds: A Novel In Vitro Multi-Cellular Approach

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University of the Health Sciences Bethesda United States

Personal Author(s):

Report Date:

2016-03-21

Pagination or Media Count:

172.0

Abstract:

The energetic properties of high-nitrogen high-N content materials have increased the interest towards their development for use in insensitive munitions. However, the use of such compounds in the production of explosives is known to lead to an increased risk of adverse health effects in munition factory workers and the general population through various occupational and environmental exposure pathways. While chemical hazard assessment with live animals has many advantages, the high cost of in vivo testing, in terms of resource consumption, animal usage, and time, only allows for the testing of a limited number of compounds.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE